Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM119562
Substrate
n/a
Meas. Tech.
Radioligand Binding
Temperature
277.15±n/a K
Ki
17±n/a nM
Comments
extracted
Citation
 Branstetter, BJ; Letavic, MA; Ly, KS; Rudolph, DA; Savall, BM; Shah, CR; Shireman, BT Fused heterocyclic compounds as orexin receptor modulators US Patent  US8680275 Publication Date 3/25/2014 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM119562
Synonyms:
US8680275, 119
Type:
Small organic molecule
Emp. Form.:
C22H19ClN6O2
Mol. Mass.:
434.878
SMILES:
Clc1ccc2oc(nc2c1)N1C[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1 |r|
Structure:
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