Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM121003
Substrate
n/a
Meas. Tech.
Fluorometric Assay
IC50
1460±n/a nM
Citation
 Guo, L; Tang, G; Wang, Z; Wong, JC; Zhang, W N-hydroxy-benzamids for the treatment of cancer US Patent  US8716285 Publication Date 5/6/2014 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM121003
Synonyms:
US8716285, 60
Type:
Small organic molecule
Emp. Form.:
C16H16ClN3O4S
Mol. Mass.:
381.834
SMILES:
ONC(=O)c1ccc2NCC(Cc2c1)NS(=O)(=O)c1ccc(Cl)cc1
Structure:
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