Reaction Details Report a problem with these data
Target
Prokineticin receptor 2
Ligand
BDBM121273
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
Temperature
310.15±n/a K
Ki
5.42±n/a nM
Comments
extracted
Citation
 Zhou, Q; Li, J; Huang, Q Prokineticin receptor antagonists and uses thereof US Patent  US8722896 Publication Date 5/13/2014 
Target
Name:
Prokineticin receptor 2
Synonyms:
Prokineticin receptor 2 (PRK2)
Type:
Enzyme
Mol. Mass.:
44473.96
Organism:
Cricetulus griseus (Chinese hamster)
Description:
G3H407
Residue:
391
Sequence:
MPPAGINMASQNKNTSFAPDLNPSQDHISSLPFNFSYSDYDLPLDGDEDMTKTQTFFAAKIVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETILDIVKNQEKIFCGQIWPVDQQLYYKSYFLFVFGLEFVGPVVAMTLCYARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTICFVTVKNNTMKYFKKMLLLHWQPSRYGSKSSADLDLKTSGVPATEEVDCIRLK
  
Inhibitor
Name:
BDBM121273
Synonyms:
US8722896, (+/-)-4-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Type:
Small organic molecule
Emp. Form.:
C29H36ClN3O4
Mol. Mass.:
526.067
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3ccn(C)c23)CCO1
Structure:
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