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Target
Prokineticin receptor 2
Ligand
BDBM121324
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
Temperature
310.15±n/a K
Ki
0.93±n/a nM
Comments
extracted
Citation
 Zhou, Q; Li, J; Huang, Q Prokineticin receptor antagonists and uses thereof US Patent  US8722896 Publication Date 5/13/2014 
Target
Name:
Prokineticin receptor 2
Synonyms:
Prokineticin receptor 2 (PRK2)
Type:
Enzyme
Mol. Mass.:
44473.96
Organism:
Cricetulus griseus (Chinese hamster)
Description:
G3H407
Residue:
391
Sequence:
MPPAGINMASQNKNTSFAPDLNPSQDHISSLPFNFSYSDYDLPLDGDEDMTKTQTFFAAKIVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETILDIVKNQEKIFCGQIWPVDQQLYYKSYFLFVFGLEFVGPVVAMTLCYARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTICFVTVKNNTMKYFKKMLLLHWQPSRYGSKSSADLDLKTSGVPATEEVDCIRLK
  
Inhibitor
Name:
BDBM121324
Synonyms:
US8722896, (-)-(2R)-2-Methyl-3-((3- hydroxy)benzylamino)-N-(9- chloro-3,3-difluoro-3,4-dihydro- 2H-1,5-benzodioxepin-7- ylmethyl)-N- isobutylpropanamide
Type:
Small organic molecule
Emp. Form.:
C25H33ClN2O4
Mol. Mass.:
460.994
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@H](C)CNCc1cccc(O)c1 |r|
Structure:
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