Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM121145
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
Temperature
310.15±n/a K
Ki
7.26±n/a nM
Comments
extracted
Citation
 Zhou, Q; Li, J; Huang, Q Prokineticin receptor antagonists and uses thereof US Patent  US8722896 Publication Date 5/13/2014 
Target
Name:
Prokineticin receptor 1
Synonyms:
Prokineticin receptor 1 (PRK1)
Type:
Enzyme
Mol. Mass.:
44908.29
Organism:
Cricetulus griseus (Chinese hamster)
Description:
G3HIE5
Residue:
399
Sequence:
MPPPAWMEPTVGALGENTTDTSTSFLSLVNARGAQAASFPFTLSYGDYDTALGEEEDVTKSWTFFAARIVIGMALVAIMLVCGVGNFIFITTLARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQVYYRSYFLLVFGLEFVGPVVAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVSVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGMPATEEVDCIGLK
  
Inhibitor
Name:
BDBM121145
Synonyms:
US8722896, (+/-)-2-Methyl-3-((2- methoxybenzyl)methylamino)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Type:
Small organic molecule
Emp. Form.:
C26H35ClN2O4
Mol. Mass.:
475.02
SMILES:
COc1cccc(CNCC(C)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Structure:
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