Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM121205
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
Temperature
310.15±n/a K
Ki
6.96±n/a nM
Comments
extracted
Citation
 Zhou, Q; Li, J; Huang, Q Prokineticin receptor antagonists and uses thereof US Patent  US8722896 Publication Date 5/13/2014 
Target
Name:
Prokineticin receptor 1
Synonyms:
Prokineticin receptor 1 (PRK1)
Type:
Enzyme
Mol. Mass.:
44908.29
Organism:
Cricetulus griseus (Chinese hamster)
Description:
G3HIE5
Residue:
399
Sequence:
MPPPAWMEPTVGALGENTTDTSTSFLSLVNARGAQAASFPFTLSYGDYDTALGEEEDVTKSWTFFAARIVIGMALVAIMLVCGVGNFIFITTLARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQVYYRSYFLLVFGLEFVGPVVAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVSVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGMPATEEVDCIGLK
  
Inhibitor
Name:
BDBM121205
Synonyms:
US8722896, (+)-(2S)-2-Methyl-3-(indol-7- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide | US8722896, (+/-)-2-Methyl-3-(indol-7- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide | US8722896, (-)-(2R)-2-Methyl-3-(indol-7- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Type:
Small organic molecule
Emp. Form.:
C27H34ClN3O3
Mol. Mass.:
484.03
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2cc[nH]c12
Structure:
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