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Target
Glucagon receptor
Ligand
BDBM123582
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
14.9±n/a nM
Citation
 Chakravarty, D; Kreutter, K; Powell, M; Shook, B; Song, F; Xu, G; Yang, S; Zhang, R; Zhao, B Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists US Patent  US8748624 Publication Date 6/10/2014 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM123582
Synonyms:
US8748624, 74
Type:
Small organic molecule
Emp. Form.:
C29H21Cl3F3N3O3
Mol. Mass.:
622.85
SMILES:
OC(=O)CCNC(=O)c1ccc(cn1)-c1cc(cc(Cl)c1CNc1ccc(c(Cl)c1)-c1ccc(Cl)cc1)C(F)(F)F
Structure:
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