Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM123644
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
20±n/a nM
Citation
 Chakravarty, D; Kreutter, K; Powell, M; Shook, B; Song, F; Xu, G; Yang, S; Zhang, R; Zhao, B Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists US Patent  US8748624 Publication Date 6/10/2014 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM123644
Synonyms:
US8748624, 158
Type:
Small organic molecule
Emp. Form.:
C31H30FN3O3
Mol. Mass.:
511.5866
SMILES:
CC(C)c1ccc(CNc2ccc(cc2)-c2ccc(F)cc2)c(c1)-c1ccc(nc1)C(=O)NCCC(O)=O
Structure:
Search PDB for entries with ligand similarity: