Reaction Details Report a problem with these data
Target
Baculoviral IAP repeat-containing protein 3 [238-349]
Ligand
BDBM130051
Substrate
n/a
Meas. Tech.
Fluorescence Polarization-Based Assays
IC50
<50±n/a nM
Citation
 Wang, S; Sun, H Bivalent diazo bicyclic Smac mimetics and the uses thereof US Patent  US8815927 Publication Date 8/26/2014 
Target
Name:
Baculoviral IAP repeat-containing protein 3 [238-349]
Synonyms:
API2 | Apoptosis inhibitor 2 | BIRC3 | BIRC3_HUMAN | Baculoviral IAP repeat-containing protein 3 | HIAP-1 | Inhibitor of apoptosis protein 1 | MIHC | RNF49 | TNFR2-TRAF-signaling complex protein 1 | cIAP-2 BIR3
Type:
BIR3 domain
Mol. Mass.:
12945.93
Organism:
Homo sapiens (Human)
Description:
Human cIAP2 BIR3 domain (residues 238-349) was used in binding assays.
Residue:
112
Sequence:
QLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTS
  
Inhibitor
Name:
BDBM130051
Synonyms:
US8815927, SM-1267
Type:
Small organic molecule
Emp. Form.:
C62H78N12O6
Mol. Mass.:
1087.3595
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)c1nc2c(cccc2[nH]1)-c1ccccc1)C(=O)CCCCCCCCC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)c1nc2c(cccc2[nH]1)-c1ccccc1 |r|
Structure:
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