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Target
Beta-secretase 2
Ligand
BDBM130199
Substrate
n/a
Meas. Tech.
Fluorescent-Peptide Cleavage Assay
Temperature
277.15±n/a K
IC50
13±n/a nM
Comments
extracted
Citation
 Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds US Patent  US8815881 Publication Date 8/26/2014 
Target
Name:
Beta-secretase 2
Synonyms:
AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:
Protein
Mol. Mass.:
56171.20
Organism:
Homo sapiens (Human)
Description:
Q9Y5Z0
Residue:
518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM130199
Synonyms:
US8815881, 161
Type:
Small organic molecule
Emp. Form.:
C22H21F4N5O2
Mol. Mass.:
463.4281
SMILES:
CN1C(N)=N[C@](C)(c2cc(Nc3ccc(cc3OC(F)(F)F)C#N)ccc2F)C(C)(C)C1=O |r,c:3|
Structure:
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