Reaction Details Report a problem with these data
Target
Arginase
Ligand
BDBM130381
Substrate
n/a
Meas. Tech.
ITC
pH
8.5±0
Kd
5.4e+2± 8e+1 nM
Citation
 Hai, Y; Edwards, JE; Van Zandt, MC; Hoffmann, KF; Christianson, DW Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis Biochemistry 53:4671-4684 (2014) [PubMed]  Article 
Target
Name:
Arginase
Synonyms:
Arginase (SmARG)
Type:
Protein
Mol. Mass.:
39912.83
Organism:
Schistosoma mansoni (flatworms)
Description:
Q6WVP6
Residue:
364
Sequence:
MLKSVATPYYPIQDEKPKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKHTVELSGSKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQTKQ
  
Inhibitor
Name:
BDBM130381
Synonyms:
(R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)piperidin-4-yl]hexanoic acid (ABH-DP)
Type:
Small organic molecule
Emp. Form.:
C18H27BCl2N2O4
Mol. Mass.:
417.135
SMILES:
N[C@](CCCCB(O)O)(C1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)C(O)=O
Structure:
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