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Target
Serine/threonine-protein kinase receptor R3
Ligand
BDBM130921
Substrate
n/a
Meas. Tech.
In Vitro Kinase Activity Assay
pH
7.5±n/a
IC50
14.59±n/a nM
Comments
extracted
Citation
 Gregor, VE Tyrosine kinase inhibitors US Patent  US8822500 Publication Date 9/2/2014 
Target
Name:
Serine/threonine-protein kinase receptor R3
Synonyms:
ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1)
Type:
Enzyme
Mol. Mass.:
56134.46
Organism:
Homo sapiens (Human)
Description:
P37023
Residue:
503
Sequence:
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
  
Inhibitor
Name:
BDBM130921
Synonyms:
US8822500, [24A]
Type:
Small organic molecule
Emp. Form.:
C30H30F4N6O2
Mol. Mass.:
582.5918
SMILES:
CC(Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2c(C)c3CN(C4CCN(C)CC4)C(=O)c3cc2[nH]1
Structure:
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