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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM131744
Substrate
n/a
Meas. Tech.
Depletion Assay
pH
7.5±n/a
IC50
5±n/a nM
Citation
 Burger, M; Lan, J; Lindvall, M; Nishiguchi, G; Tetalman, M PIM kinase inhibitors and methods of their use US Patent  US8829193 Publication Date 9/9/2014 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM131744
Synonyms:
US8829193, 18
Type:
Small organic molecule
Emp. Form.:
C20H18ClF2N5OS
Mol. Mass.:
449.905
SMILES:
NC1CN(CCC1Cl)c1ccncc1NC(=O)c1csc(n1)-c1c(F)cccc1F
Structure:
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