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Reaction Details
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TargetChymase
LigandBDBM134262
Substrate/Competitorn/a
Meas. Tech.Inhibitory Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 4±n/a nM
Commentsextracted
Citation Muto, TTanaka, TFutamura, JImajo, SSugawara, H Seven-membered ring compound and pharmaceutical use therefor US Patent US8846660 Publication Date 9/30/2014
More Info.:Get all data from this article,  Assay Method
 
Chymase
Name:Chymase
Synonyms:Alpha-chymase | Chymase precursor | Mast cell protease I
Type:Enzyme
Mol. Mass.:27340.12
Organism:Homo sapiens (Human)
Description:n/a
Residue:247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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  Blast E-value cutoff:
BDBM134262
NameBDBM134262
Synonyms:US8846660, 30
TypeSmall organic molecule
Emp. Form.C29H28ClF2N5O6
Mol. Mass.616.012
SMILESCOc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1cc(F)cc(F)c1 |r|
Structure
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n/a