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TargetChymase
LigandBDBM134266
Substrate/Competitorn/a
Meas. Tech.Inhibitory Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 10±n/a nM
Commentsextracted
Citation Muto, TTanaka, TFutamura, JImajo, SSugawara, H Seven-membered ring compound and pharmaceutical use therefor US Patent US8846660 Publication Date 9/30/2014
More Info.:Get all data from this article,  Assay Method
 
Chymase
Name:Chymase
Synonyms:Alpha-chymase | Chymase precursor | Mast cell protease I
Type:Enzyme
Mol. Mass.:27340.12
Organism:Homo sapiens (Human)
Description:n/a
Residue:247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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  Blast E-value cutoff:
BDBM134266
NameBDBM134266
Synonyms:US8846660, 40
TypeSmall organic molecule
Emp. Form.C30H30ClFN4O6
Mol. Mass.597.034
SMILESCOc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1ccc(F)cc1 |r|
Structure
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n/a