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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM135431
Substrate/Competitorn/a
Meas. Tech.FRET Assay
IC50 38±n/a nM
Citation Christopher, MPFradera Llinas, FXMachacek, MMartinez, MReutershan, MHShizuka, MSun, BThompson, CFTrotter, BWVoss, MEAltman, MDBogen, SLDoll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent US8846657 Publication Date 9/30/2014
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:MDM2-MDMX
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:n/a
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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  Blast E-value cutoff:
BDBM135431
NameBDBM135431
Synonyms:US8846657, 17.6
TypeSmall organic molecule
Emp. Form.C28H29ClF3N7O3
Mol. Mass.604.023
SMILESFC(F)(F)[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CCC[C@@H]23)CC1 |r,wU:35.39,7.7,wD:39.42,4.3,(7.25,-3.84,;5.92,-4.61,;5.92,-6.15,;7.25,-5.38,;4.58,-3.84,;4.58,-2.3,;3.25,-1.53,;1.92,-2.3,;.58,-1.53,;.58,.01,;1.49,1.26,;.58,2.5,;-.88,2.03,;-2.21,2.8,;-3.55,2.03,;-3.55,.49,;-2.21,-.28,;-2.21,-1.82,;-.88,-2.59,;-.88,-4.13,;-2.21,-4.9,;-3.55,-4.13,;-4.88,-4.9,;-3.55,-2.59,;-.88,.49,;-4.88,2.8,;-6.35,2.32,;-7.25,3.57,;-6.35,4.81,;-7.12,6.15,;-4.88,4.34,;3.03,1.26,;3.8,-.08,;5.34,-.08,;6.11,1.26,;5.34,2.59,;5.81,4.06,;4.57,4.96,;3.32,4.06,;3.8,2.59,;1.92,-3.84,;3.25,-4.61,)|
Structure
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