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Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Ligand
BDBM137962
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Temperature
303.15±n/a K
IC50
>1000±n/a nM
Comments
extracted
Citation
 Motomura, T; Nagamori, H; Suzawa, K; Ito, H; Morita, T; Kobayashi, S; Shinkai, H Fluorene compound and pharmaceutical use thereof US Patent  US8871934 Publication Date 10/28/2014 
Target
Name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Synonyms:
PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2)
Type:
Enzyme
Mol. Mass.:
46153.78
Organism:
Homo sapiens (Human)
Description:
Q15119
Residue:
407
Sequence:
MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
  
Inhibitor
Name:
BDBM137962
Synonyms:
US8871934, 555
Type:
Small organic molecule
Emp. Form.:
C20H17F3N2O
Mol. Mass.:
358.357
SMILES:
Cc1nn(C)c(C)c1-c1ccc2-c3ccccc3C(O)(c2c1)C(F)(F)F
Structure:
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