Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
LigandBDBM137974
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8±n/a
Temperature303.15±n/a K
IC50>1000±n/a nM
Commentsextracted
Citation Motomura, TNagamori, HSuzawa, KIto, HMorita, TKobayashi, SShinkai, H Fluorene compound and pharmaceutical use thereof US Patent US8871934 Publication Date 10/28/2014
More Info.:Get all data from this article,  Assay Method
 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Name:[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Synonyms:Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2)
Type:Enzyme
Mol. Mass.:46153.78
Organism:Homo sapiens (Human)
Description:Q15119
Residue:407
Sequence:
MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM137974
NameBDBM137974
Synonyms:US8871934, 567
TypeSmall organic molecule
Emp. Form.C20H17F3N2O
Mol. Mass.358.357
SMILESCc1nn(C)c(C)c1-c1cccc2c1-c1ccccc1C2(O)C(F)(F)F |(-1.15,2.27,;.39,2.27,;.87,3.73,;2.41,3.73,;3.18,5.07,;2.89,2.27,;4.22,1.5,;1.64,1.36,;1.64,-.18,;2.97,-.95,;2.97,-2.49,;1.64,-3.26,;.31,-2.49,;.31,-.95,;-1.16,-.47,;-1.78,.94,;-3.32,1.1,;-4.22,-.15,;-3.59,-1.56,;-2.06,-1.72,;-1.16,-2.96,;-.39,-4.3,;-2.49,-3.73,;-3.82,-2.96,;-3.26,-5.07,;-1.72,-5.07,)|
Structure
n/a