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Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
LigandBDBM137986
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8±n/a
Temperature303.15±n/a K
IC50 19±n/a nM
Commentsextracted
Citation Motomura, TNagamori, HSuzawa, KIto, HMorita, TKobayashi, SShinkai, H Fluorene compound and pharmaceutical use thereof US Patent US8871934 Publication Date 10/28/2014
More Info.:Get all data from this article,  Assay Method
 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Name:[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Synonyms:Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2)
Type:Enzyme
Mol. Mass.:46153.78
Organism:Homo sapiens (Human)
Description:Q15119
Residue:407
Sequence:
MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
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  Blast E-value cutoff:
BDBM137986
NameBDBM137986
Synonyms:US8871934, 579
TypeSmall organic molecule
Emp. Form.C22H17F3N4O
Mol. Mass.410.3918
SMILESCn1cc(cn1)-c1cc2c(-c3ccccc3C2(O)C(F)(F)F)c(c1)-c1cnn(C)c1
Structure
n/a