Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM85507
Substrate
n/a
Meas. Tech.
FP Assay
IC50
289±n/a nM
Citation
 Graef, IA; Alhamadsheh, M Identification of stabilizers of multimeric proteins US Patent  US8877795 Publication Date 11/4/2014 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM85507
Synonyms:
CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumic acid (Hit 16) | US10278929, Niflumic acid | US11337935, Compound Niflumic-acid | US20240002326, Compound Niflumic acid
Type:
Small organic molecule
Emp. Form.:
C13H9F3N2O2
Mol. Mass.:
282.218
SMILES:
OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F
Structure:
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