Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM139317
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
2272±n/a nM
Comments
extracted
Citation
 van Duzer, JH; Mazitschek, R; Ding, Y; Yu, N; Cao, Y; Liu, Y Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof US Patent  US8614223 Publication Date 12/24/2013 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM139317
Synonyms:
US8614223, 95
Type:
Small organic molecule
Emp. Form.:
C16H18N4O3
Mol. Mass.:
314.3391
SMILES:
ONC(=O)c1cnc(NC2(CCOCC2)c2ccccc2)nc1
Structure:
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