Target
Sodium/calcium exchanger 1
Ligand
BDBM140572
Substrate
n/a
Meas. Tech.
Reverse Mode Assay
IC50
300±n/a nM
Citation
 Czechtizky, WWeston, JRackelmann, NPodeschwa, MArndt, PWirth, KGoegelein, HRitzeler, OKraft, VBellevergue, PMcCort, G Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals US Patent  US8912224 Publication Date 12/16/2014 
Target
Name:
Sodium/calcium exchanger 1
Synonyms:
CNC | NAC1_HUMAN | NCX1 | SLC8A1 | Sodium/calcium exchanger 1(NCX1)
Type:
Protein
Mol. Mass.:
108507.88
Organism:
Homo sapiens (Human)
Description:
P32418
Residue:
973
Sequence:
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
  
Inhibitor
Name:
BDBM140572
Synonyms:
US8912224, 1
Type:
Small organic molecule
Emp. Form.:
C25H24N4O3S
Mol. Mass.:
460.548
SMILES:
CCn1cc(CNC(=O)c2cnc(Oc3ccc4OC(CCc4c3)c3ccccc3)s2)cn1
Structure:
Search PDB for entries with ligand similarity: