Reaction Details Report a problem with these data
Target
EF-hand calcium-binding domain-containing protein 4B
Ligand
BDBM141406
Substrate
n/a
Meas. Tech.
In-Vitro Inhibition Assay
Temperature
310.15±n/a K
IC50
181.1±n/a nM
Comments
extracted
Citation
 Muthuppalaniappan, M; Viswanadha, S; Merikapudi, GS; Vakkalanka, SK Modulators of calcium release-activated calcium channel US Patent  US8921364 Publication Date 12/30/2014 
Target
Name:
EF-hand calcium-binding domain-containing protein 4B
Synonyms:
CRACR2A | Calcium release-activated calcium (CRAC) | EFC4B_HUMAN | EFCAB4B | RAB46
Type:
Protein
Mol. Mass.:
45570.29
Organism:
Homo sapiens (Human)
Description:
Q9BSW2
Residue:
395
Sequence:
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRCVGGHWPVLRAPPRSLGSEGPV
  
Inhibitor
Name:
BDBM141406
Synonyms:
US10668051, Compound Example 37 | US8921364, 37
Type:
Small organic molecule
Emp. Form.:
C19H17ClFN5OS
Mol. Mass.:
417.888
SMILES:
Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(C2CC2)c(Cl)c1C1CC1
Structure:
Search PDB for entries with ligand similarity: