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Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM107738
Substrate
n/a
Meas. Tech.
Inhibition Spectra Assay
Temperature
310.15±n/a K
IC50
65.6±n/a nM
Comments
extracted
Citation
 Dounay, AB; McAllister, LA; Parikh, VD; Rong, S; Verhoest, PR KAT II inhibitors US Patent  US8933095 Publication Date 1/13/2015 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:
Enzyme
Mol. Mass.:
47353.09
Organism:
Homo sapiens (Human)
Description:
Q8N5Z0
Residue:
425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
  
Inhibitor
Name:
BDBM107738
Synonyms:
CHEMBL2347113 | US8933095, 22
Type:
Small organic molecule
Emp. Form.:
C15H18N4O3
Mol. Mass.:
302.3284
SMILES:
COc1cccc(Cc2nn(C)c3N(O)C(=O)[C@@H](N)Cc23)c1 |r|
Structure:
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