Reaction Details Report a problem with these data
Target
Fibroblast growth factor 2
Ligand
BDBM142256
Substrate
n/a
Meas. Tech.
ADP-Glo Kinase Assay
Temperature
298.15±n/a K
IC50
4.5±n/a nM
Comments
extracted
Citation
 Funasaka, S; Okada, T; Tanaka, K; Nagao, S; Ohashi, I; Yamane, Y; Nakatani, Y; Karoji, Y Monocyclic pyridine derivative US Patent  US8933099 Publication Date 1/13/2015 
Target
Name:
Fibroblast growth factor 2
Synonyms:
Basic fibroblast growth factor | FGF-2 | FGF2 | FGF2_HUMAN | FGFB | Fibroblast growth factor 2 (bFGF) | Fibroblast growth factor receptor 2 (FGF-2) | HBGF-2 | Heparin-binding growth factor 2
Type:
Protein
Mol. Mass.:
30803.89
Organism:
Homo sapiens (Human)
Description:
P09038
Residue:
288
Sequence:
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
  
Inhibitor
Name:
BDBM142256
Synonyms:
US8933099, 22 | US9951047, Compound (I)
Type:
Small organic molecule
Emp. Form.:
C32H37N5O6
Mol. Mass.:
587.6661
SMILES:
CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Structure:
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