Reaction Details Report a problem with these data
Target
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
Ligand
BDBM142771
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
7000±n/a nM
Citation
 Li, W; Wang, Y; Juan, H Lithocholic acid analogues that inhibit sialyltransferase US Patent  US8940719 Publication Date 1/27/2015 
Target
Name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
Synonyms:
SIA4B_RAT | Siat4b | Siat5 | St3gal2 | alpha-2,3-sialyltransferase
Type:
Enzyme
Mol. Mass.:
40178.44
Organism:
Rattus norvegicus (Rat)
Description:
Q11205
Residue:
350
Sequence:
MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGTLGGTHRVKLVPGYTGQQRLVKEGLSGKSCTCSRCMGDAGTSEWFDSHFDSNISPVWTRDNMNLTPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDILAKASKIEVYRGN
  
Inhibitor
Name:
BDBM142771
Synonyms:
US8940719, 20
Type:
Small organic molecule
Emp. Form.:
C33H56N3O6P
Mol. Mass.:
621.788
SMILES:
CCOP(=O)(OCC)C(Cc1cn(CCC[C@@H](C)C2CC[C@H]3C4CC[C@@H]5C[C@H](O)CC[C@]5(C)C4CC[C@]23C)nn1)C(O)=O |r,w:8.44|
Structure:
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