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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM143779
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Temperature
277.15±n/a K
Ki
16±n/a nM
Comments
extracted
Citation
 Gelin, CF; Lebold, TP; Shireman, BT Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US8969352 Publication Date 3/3/2015 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM143779
Synonyms:
US10183953, Example 40 | US8969352, 40 | US9611277, Example 40 | US9845333, 40
Type:
Small organic molecule
Emp. Form.:
C24H21F3N4O3
Mol. Mass.:
470.4437
SMILES:
COc1cccc(-c2ncccn2)c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:21:20:16.17:33,14:16:20.19:33|
Structure:
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