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Target
Apoptosis regulator Bcl-2
Ligand
BDBM145219
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Temperature
298.15±n/a K
Ki
<0.01±n/a nM
Comments
extracted
Citation
 Ding, H; Doherty, GA; Elmore, SW; Hexamer, L; Kunzer, AR; Park, C; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, L; Wendt, MD; Czabotar, PE; Lessene, GL; Colman, PM Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent  US8952157 Publication Date 2/10/2015 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM145219
Synonyms:
US8952157, 410 | US9303025, 410
Type:
Small organic molecule
Emp. Form.:
C45H46Cl2F3N5O6S
Mol. Mass.:
912.843
SMILES:
CC1(C)CC(=C(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3cnc(OCC4CCC(F)(F)CC4)c(Cl)c3)c(Oc3cc4cc[nH]c4cc3F)c2)CO1)c1ccc(Cl)cc1 |t:4|
Structure:
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