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Target
Lymphokine-activated killer T-cell-originated protein kinase
Ligand
BDBM149042
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.5±n/a nM
Comments
extracted
Citation
 Nakamura, Y; Matsuo, Y; Hisada, S; Ahmed, F; Huntley, R; Sajjadi-Hashemi, Z; Jenkins, DM; Kargbo, RB; Cui, W; Gauuan, PJ; Walker, JR; Decornez, H; Gurram, M Tricyclic compounds and PBK inhibitors containing the same US Patent  US8962648 Publication Date 2/24/2015 
Target
Name:
Lymphokine-activated killer T-cell-originated protein kinase
Synonyms:
2.7.12.2 | CT84 | Cancer/testis antigen 84 | MAPKK-like protein kinase | Nori-3 | PBK | PDZ-binding kinase | SPK | Spermatogenesis-related protein kinase | T-LAK cell-originated protein kinase | TOPK | TOPK_HUMAN
Type:
n/a
Mol. Mass.:
36072.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
322
Sequence:
MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV
  
Inhibitor
Name:
BDBM149042
Synonyms:
US8962648, 276
Type:
Small organic molecule
Emp. Form.:
C19H15FN2O2S
Mol. Mass.:
354.398
SMILES:
NCCc1ccc(cc1F)-c1c(O)ccc2[nH]c(=O)c3sccc3c12
Structure:
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