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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM150778
Substrate
n/a
Meas. Tech.
Alpha-glucosidase Assay
Temperature
583.3±0 K
IC50
3.711e+4± 5e+1 nM
Citation
 Rahim, F; Ullah, K; Ullah, H; Wadood, A; Taha, M; Ur Rehman, A; uddin, I; Ashraf, M; Shaukat, A; Rehman, W; Hussain, S; Khan, KM Triazinoindole analogs as potent inhibitors of a-glucosidase: synthesis, biological evaluation and molecular docking studies. Bioorg Chem 58:81-7 (2015) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM150778
Synonyms:
2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(3-bromophenyl)-ethanone (11)
Type:
Small organic molecule
Emp. Form.:
C17H11BrN4OS
Mol. Mass.:
399.264
SMILES:
Brc1cccc(c1)C(=O)CSc1nnc2c(n1)[nH]c1ccccc21
Structure:
Search PDB for entries with ligand similarity: