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TargetCytochrome P450 11B2 (CYP11B2)
LigandBDBM286222
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 0.450±n/a nM
Citation Ali, ABennett, DJCai, JCarswell, ECooke, AHoyt, SBLo, MLondon, CMacLean, JPark, MKRatcliffe, PTaylor, JAWhitehead, BXiong, Y Imidazopyridyl compounds as aldosterone synthase inhibitors US Patent US9518055 Publication Date 12/13/2016
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 11B2 (CYP11B2)
Name:Cytochrome P450 11B2 (CYP11B2)
Synonyms:Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:Protein
Mol. Mass.:57582.15
Organism:Homo sapiens (Human)
Description:P19099
Residue:503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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  Blast E-value cutoff:
BDBM286222
NameBDBM286222
Synonyms:6-fluoro-3-methyl-2-(5- methylpyridin-3-yl)imidazo[1,2- a]pyridine | US9518055, Example 19
TypeSmall organic molecule
Emp. Form.C14H12FN3
Mol. Mass.241.2636
SMILESCc1c(nc2ccc(F)cn12)-c1cncc(C)c1
Structure
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