Reaction Details Report a problem with these data
Target
2-acylglycerol O-acyltransferase 2
Ligand
BDBM152811
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
277.15±n/a K
IC50
40±n/a nM
Comments
extracted
Citation
 Gonzalez-Garcia, MR; Fernandez, MC Morpholinyl derivatives useful as MOGAT-2 inhibitors US Patent  US8993568 Publication Date 3/31/2015 
Target
Name:
2-acylglycerol O-acyltransferase 2
Synonyms:
2-acylglycerol O-acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2) | DC5 | DGAT2L5 | Diacylglycerol O-acyltransferase candidate 5 | Diacylglycerol acyltransferase 2-like protein 5 | MGAT2 | MOGAT2 | MOGT2_HUMAN | Monoacylglycerol Acyltransferase 2 (MGAT2) | Monoacylglycerol O-acyltransferase 2 | hDC5 | hMGAT2
Type:
Enzyme
Mol. Mass.:
38210.80
Organism:
Homo sapiens (Human)
Description:
Q3SYC2
Residue:
334
Sequence:
MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
  
Inhibitor
Name:
BDBM152811
Synonyms:
US8993568, 14
Type:
Small organic molecule
Emp. Form.:
C20H22F4N2O3S
Mol. Mass.:
446.459
SMILES:
CS(=O)(=O)N[C@@H](c1ccc(CN2CCOC(C2)c2ccc(F)cc2)cc1)C(F)(F)F |r|
Structure:
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