Reaction Details
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Calcium release-activated calcium channel protein 1
Ligand
BDBM152939
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
310.15±n/a K
IC50
160.5±n/a nM
Comments
extracted
Citation
Muthuppalaniappan, M; Viswanadha, S; Varanasi, KV; Merikapudi, GS; Vakkalanka, SK Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer US Patent US8993612 Publication Date 3/31/2015 More Info.:
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
Inhibitor
Name:
BDBM152939
Synonyms:
US8993612, 30
Type:
Small organic molecule
Emp. Form.:
C21H16F4N6O
Mol. Mass.:
444.385
SMILES:
Fc1cc(NC(=O)Cn2nnc3ccccc23)ccc1-n1nc(cc1C1CC1)C(F)(F)F
Structure:
