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TargetIKK epsilon/TBK1
LigandBDBM50389967
Substrate/Competitorn/a
Meas. Tech.KinEASE-STK Assay
IC50 1.4e+2± 0 nM
Citation Richters, ABasu, DEngel, JErcanoglu, MSBalke-Want, HTesch, RThomas, RKRauh, D Identification and further development of potent TBK1 inhibitors. ACS Chem Biol10:289-98 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
IKK epsilon/TBK1
Name:IKK epsilon/TBK1
Synonyms:Serine/threonine-protein kinase TBK1 | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1)
Type:protein
Mol. Mass.:83645.20
Organism:Homo sapiens (Human)
Description:Q9UHD2
Residue:729
Sequence:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50389967
NameBDBM50389967
Synonyms:Aminopyrimidine (Scaffold VI) | CHEMBL1614709
TypeSmall organic molecule
Emp. Form.C24H30FN7O
Mol. Mass.451.5397
SMILESCN1CCN(CC1)c1ccc(Nc2ncc(F)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)cc1C |c:24|
Structure
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n/a