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TargetSARS Coronavirus Coronavirus Papain-Like Protease
LigandBDBM31524
Substrate/Competitorn/a
Meas. Tech.Fluorimetric Assay
pH7.5±n/a
IC50 2.3e+2± 7e+1 nM
Commentsextracted
Citation Lee, HLei, HSantarsiero, BDGatuz, JLCao, SRice, AJPatel, KSzypulinski, MZOjeda, IGhosh, AKJohnson, ME Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. ACS Chem Biol10:1456-65 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
SARS Coronavirus Coronavirus Papain-Like Protease
Name:SARS Coronavirus Coronavirus Papain-Like Protease
Synonyms:SARS-CoV PLpro | SARS-CoV papain-like protease (SARS-PLpro)
Type:Hydrolase
Mol. Mass.:35352.30
Organism:Human SARS coronavirus (SARS-CoV)
Description:The SARS-CoV PLpro enzyme (residues 1541 -1855) was expressed and purified from E. coli.
Residue:315
Sequence:
EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPS
DDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLAL
QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES
AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS
FVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPV
TDVFYKETSYTTTIK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM31524
NameBDBM31524
Synonyms:5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide (I-1) | AKOS015840255 | GRL0617 | Naphthalene and Benzamide Derivative, 25 | SARS-CoV-2 PLpro Inhibitor, GRL0617 (1) | med.21724, Compound 159
TypeSmall organic molecule
Emp. Form.C20H20N2O
Mol. Mass.304.3856
SMILESC[C@@H](NC(=O)c1cc(N)ccc1C)c1cccc2ccccc12 |r|
Structure
n/a