| Reaction Details |
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 | Report a problem with these data |
| Target | SARS Coronavirus Coronavirus Papain-Like Protease |
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| Ligand | BDBM31524 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorimetric Assay |
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| pH | 7.5±n/a |
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| IC50 | 2.3e+2± 7e+1 nM |
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| Comments | extracted |
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| Citation |  Lee, H; Lei, H; Santarsiero, BD; Gatuz, JL; Cao, S; Rice, AJ; Patel, K; Szypulinski, MZ; Ojeda, I; Ghosh, AK; Johnson, ME Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. ACS Chem Biol10:1456-65 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| SARS Coronavirus Coronavirus Papain-Like Protease |
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| Name: | SARS Coronavirus Coronavirus Papain-Like Protease |
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| Synonyms: | SARS-CoV PLpro | SARS-CoV papain-like protease (SARS-PLpro) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 35352.30 |
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| Organism: | Human SARS coronavirus (SARS-CoV) |
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| Description: | The SARS-CoV PLpro enzyme (residues 1541 -1855) was expressed and purified from E. coli. |
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| Residue: | 315 |
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| Sequence: | EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPS
DDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLAL
QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES
AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS
FVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPV
TDVFYKETSYTTTIK
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| BDBM31524 |
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| Name | BDBM31524 |
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| Synonyms: | 5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide (I-1) | AKOS015840255 | GRL0617 | Naphthalene and Benzamide Derivative, 25 | SARS-CoV-2 PLpro Inhibitor, GRL0617 (1) | med.21724, Compound 159 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N2O |
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| Mol. Mass. | 304.3856 |
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| SMILES | C[C@@H](NC(=O)c1cc(N)ccc1C)c1cccc2ccccc12 |r| |
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| Structure |  |
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| n/a |
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