Reaction Details Report a problem with these data
Target
Lysosomal protective protein
Ligand
BDBM156722
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.5±n/a
Temperature
298.15±n/a K
IC50
6830±n/a nM
Comments
extracted
Citation
 Ruf, S; Sadowski, T; Wirth, K; Schreuder, H; Buning, C Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals US Patent  US9029559 Publication Date 5/12/2015 
Target
Name:
Lysosomal protective protein
Synonyms:
CTSA | Cathepsin A | Cathepsin A (CTSA) | Lysosomal protective protein | PPGB | PPGB_HUMAN
Type:
Protein
Mol. Mass.:
54465.95
Organism:
Homo sapiens (Human)
Description:
P10619
Residue:
480
Sequence:
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
  
Inhibitor
Name:
BDBM156722
Synonyms:
US9029559, 138
Type:
Small organic molecule
Emp. Form.:
C23H19F3N2O3
Mol. Mass.:
428.4038
SMILES:
Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccc(cc1)C(F)(F)F
Structure:
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