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TargetCathepsin A (CTSA)
LigandBDBM156865
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH5.5±n/a
Temperature298.15±n/a K
IC50 73.7±n/a nM
Commentsextracted
Citation Ruf, SSadowski, TWirth, KSchreuder, HBuning, C Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals US Patent US9029559 Publication Date 5/12/2015
More Info.:Get all data from this article,  Assay Method
 
Cathepsin A (CTSA)
Name:Cathepsin A (CTSA)
Synonyms:Cathepsin A | Lysosomal protective protein
Type:Protein
Mol. Mass.:54465.95
Organism:Homo sapiens (Human)
Description:P10619
Residue:480
Sequence:
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK
HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI
ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC
CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD
LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD
MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME
VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
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  Blast E-value cutoff:
BDBM156865
NameBDBM156865
Synonyms:US9029559, 301
TypeSmall organic molecule
Emp. Form.C23H20F2N2O5
Mol. Mass.442.4121
SMILESCOc1ccc(F)cc1-c1nc(ccc1OC)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a