Reaction Details Report a problem with these data
Target
Lysosomal protective protein
Ligand
BDBM157040
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.5±n/a
Temperature
298.15±n/a K
IC50
50.65±n/a nM
Comments
extracted
Citation
 Ruf, S; Sadowski, T; Wirth, K; Schreuder, H; Buning, C Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals US Patent  US9029559 Publication Date 5/12/2015 
Target
Name:
Lysosomal protective protein
Synonyms:
CTSA | Cathepsin A | Cathepsin A (CTSA) | Lysosomal protective protein | PPGB | PPGB_HUMAN
Type:
Protein
Mol. Mass.:
54465.95
Organism:
Homo sapiens (Human)
Description:
P10619
Residue:
480
Sequence:
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
  
Inhibitor
Name:
BDBM157040
Synonyms:
US9029559, 493
Type:
Small organic molecule
Emp. Form.:
C22H17Cl2FN2O4
Mol. Mass.:
463.286
SMILES:
COc1ccc(nc1-c1cccc(F)c1Cl)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Structure:
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