Reaction Details Report a problem with these data
Target
Lysosomal protective protein
Ligand
BDBM157095
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.5±n/a
Temperature
298.15±n/a K
IC50
2180±n/a nM
Comments
extracted
Citation
 Ruf, S; Sadowski, T; Wirth, K; Schreuder, H; Buning, C Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals US Patent  US9029559 Publication Date 5/12/2015 
Target
Name:
Lysosomal protective protein
Synonyms:
CTSA | Cathepsin A | Cathepsin A (CTSA) | Lysosomal protective protein | PPGB | PPGB_HUMAN
Type:
Protein
Mol. Mass.:
54465.95
Organism:
Homo sapiens (Human)
Description:
P10619
Residue:
480
Sequence:
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
  
Inhibitor
Name:
BDBM157095
Synonyms:
US9029559, 567
Type:
Small organic molecule
Emp. Form.:
C21H17ClN2O3
Mol. Mass.:
380.824
SMILES:
OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1Cl)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: