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Target
Serine/threonine-protein kinase receptor R3
Ligand
BDBM51425
Substrate
n/a
Meas. Tech.
Radiometric Assay
IC50
25±n/a nM
Citation
 Klar, J; Vöhringer, V; Telser, J; Lobell, M; Süβmeier, F; Li, VM; Böttger, M; Golz, S; Lang, D; Schlemmer, K; Schlange, T; Schall, A; Fu, W Hydroxymethylaryl-substituted pyrrolotriazines as ALK1 inhibitors US Patent  US9040691 Publication Date 5/26/2015 
Target
Name:
Serine/threonine-protein kinase receptor R3
Synonyms:
ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1)
Type:
Enzyme
Mol. Mass.:
56134.46
Organism:
Homo sapiens (Human)
Description:
P37023
Residue:
503
Sequence:
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
  
Inhibitor
Name:
BDBM51425
Synonyms:
US9040691, 21
Type:
n/a
Emp. Form.:
C17H18FN5O2
Mol. Mass.:
343.3555
SMILES:
Nc1ncnn2c(cc(-c3ccc(CO)c(F)c3)c12)N1CCOCC1
Structure:
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