Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM161623
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
pH
7.4±n/a
IC50
2.6±n/a nM
Comments
extracted
Citation
 Le Tiran, A; Le Diguarher, T; Starck, J; Henlin, J; Guillouzic, A; De Nanteuil, G; Geneste, O; Fejes, I; Tatai, J; Nyerges, M; Davidson, JE; Murray, JB; Chen, I; Durand, D Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9108983 Publication Date 8/18/2015 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM161623
Synonyms:
US9108983, Example 440
Type:
Small organic molecule
Emp. Form.:
C42H43FN6O5
Mol. Mass.:
730.8264
SMILES:
COc1cc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(cc1F)-c1cc(C(=O)N(c2cc(C#N)n(C)c2C)c2ccc(O)cc2)c(C)n1C
Structure:
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