Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM162752
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Temperature
298.15±n/a K
IC50
>10000±n/a nM
Comments
extracted
Citation
 Hebach, C; Joly, E; Kallen, J; Ternois, JG; Tintelnot-Blomley, M Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease US Patent  US9056843 Publication Date 6/16/2015 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM162752
Synonyms:
US9056843, 43
Type:
Small organic molecule
Emp. Form.:
C22H20F3N3O2
Mol. Mass.:
415.4083
SMILES:
FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)N1CCC(Cc2ccccc2)CC1
Structure:
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