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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM163766
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
pH
7.4±n/a
IC50
80±n/a nM
Comments
extracted
Citation
 Pasternak, A; Blizzard, T; Chobanian, H; de Jesus, R; Ding, F; Dong, S; Gude, C; Kim, D; Tang, H; Walsh, S; Pio, B; Jiang, J Inhibitors of the renal outer medullary potassium channel US Patent  US9062070 Publication Date 6/23/2015 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-sensitive inward rectifier potassium channel 1 | Inward rectifier K(+) channel Kir1.1 | KAB-1 | KCNJ1_RAT | Kcnj1 | Potassium channel (ATP modulatory) | Potassium channel, inwardly rectifying subfamily J member 1 | Renal Outer Medullary Potassium (ROMK) | Renal Outer Medullary Potassium (ROMK1) | Romk1 | The Renal Outer Medullary Potassium (ROMK) channel (Kir1.1)
Type:
Enzyme
Mol. Mass.:
44976.27
Organism:
Rattus norvegicus (Rat)
Description:
P35560
Residue:
391
Sequence:
MGASERSVFRVLIRALTERMFKHLRRWFITHIFGRSRQRARLVSKEGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM
  
Inhibitor
Name:
BDBM163766
Synonyms:
US9062070, 21
Type:
Small organic molecule
Emp. Form.:
C24H22F2N8O2
Mol. Mass.:
492.4807
SMILES:
Fc1ccc([C@H]2CN3CCN(C[C@@H]3CO2)C(=O)C2CCc3nc(ccc23)-n2cnnn2)c(F)c1[N+]#[C-] |r|
Structure:
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