Reaction Details Report a problem with these data
Target
Uncharacterized protein YOR062C
Ligand
BDBM50031467
Substrate
n/a
Meas. Tech.
Tyrosinase Inhibition Assay
pH
6.8±n/a
IC50
1.900e+4± 7.5e+2 nM
Comments
extracted
Citation
 Xie, W; Zhang, J; Ma, X; Yang, W; Zhou, Y; Tang, X; Zou, Y; Li, H; He, J; Xie, S; Zhao, Y; Liu, F Synthesis and biological evaluation of kojic acid derivatives containing 1,2,4-triazole as potent tyrosinase inhibitors. Chem Biol Drug Des 86:1087-92 (2015) [PubMed]  Article 
Target
Name:
Uncharacterized protein YOR062C
Synonyms:
Tyrosinase | YO062_YEAST
Type:
Protein
Mol. Mass.:
31886.70
Organism:
Agaricus bisporus (Mushroom)
Description:
O00024
Residue:
268
Sequence:
MTSLDDSVLTKKNIALLDNATNYIRPAIDYFHFKFNYDSLDVSTTWRLLLKMRKHKLLRLPSCSSENEFDYSIYMARLYHCIWRRWSIKHFNLDEYKIDPLSINWNKEIDVTVLYGPDLVGIHEREQPTPTDFPMGNIKEQGKQLLDVRKEGSASSLLKKGSVFYSKGKWLSQRSISFDDTVRRRDIDKRGRFRESCVLINDVEQFQNYSIVWDESRHRYRRQALPDTYDYEHLYPNGDETPRNTPHDNIIIHQNLHSITEGSYIYIK
  
Inhibitor
Name:
BDBM50031467
Synonyms:
5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hydroxy-2-hydroxymethyl-pyran-4-one | CHEMBL287556 | Kojic Acid | US10857082, Kojic acid | US9422261, Kojic acid | US9682910, kojic acid
Type:
Small organic molecule
Emp. Form.:
C6H6O4
Mol. Mass.:
142.1094
SMILES:
OCc1cc(=O)c(O)co1
Structure:
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