Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM167446
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Assay
IC50
>10000±n/a nM
Citation
 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt US Patent  US9073906 Publication Date 7/7/2015 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3
Type:
Enzyme
Mol. Mass.:
44141.72
Organism:
Homo sapiens (Human)
Description:
Purified recombinant human 11beta-HSD2.
Residue:
405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
  
Inhibitor
Name:
BDBM167446
Synonyms:
US9073906, 175
Type:
Small organic molecule
Emp. Form.:
C23H27Cl3N4O4S
Mol. Mass.:
561.909
SMILES:
NC(=O)C12CC3CC(C1)C(NC(=O)CN1CC(=C)CN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 |TLB:10:9:6:3.4.8,10:9:3.34.8:6.5.33,1:3:6:32.33.9,THB:1:3:6.5.33:9,4:3:6.5.33:9,4:5:3.34.8:9,34:3:6:32.33.9,34:32:6:3.4.8,(9.34,2.32,;7.85,2.72,;7.45,4.21,;6.76,1.63,;5.99,2.96,;4.45,2.96,;3.68,1.63,;4.45,.3,;5.99,.3,;4,-1.13,;2.67,-1.9,;1.33,-1.13,;1.33,.41,;,-1.9,;-1.33,-1.13,;-1.33,.41,;-2.67,1.18,;-2.67,2.72,;-4,.41,;-4,-1.13,;-5.33,-1.9,;-6.67,-1.13,;-6.67,.41,;-8,-1.9,;-8,-3.44,;-9.34,-4.21,;-6.67,-4.21,;-5.33,-3.44,;-4,-4.21,;-2.67,-1.9,;-3.44,-3.23,;-1.9,-3.23,;5.37,-.34,;4.58,.96,;6.76,0,)|
Structure:
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