Reaction Details Report a problem with these data
Target
Acyl-CoA desaturase 1
Ligand
BDBM174867
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Temperature
298.15±n/a K
IC50
7±n/a nM
Comments
extracted
Citation
 Yang, S; Kuo, G; Gaul, MD; Rano, TA Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors US Patent  US9102669 Publication Date 8/11/2015 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM174867
Synonyms:
US9102669, 33
Type:
Small organic molecule
Emp. Form.:
C22H20FN5O2
Mol. Mass.:
405.4249
SMILES:
COc1ccc(nc1)-c1ccc(nn1)N1CCC(CC1)c1noc2ccc(F)cc12
Structure:
Search PDB for entries with ligand similarity: