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TargetBcl-xL/BAK
LigandBDBM174845
Substrate/Competitorn/a
Meas. Tech.Isothermal Titration Calorimetry Assays
Kd 40±n/a nM
Citation Pellecchia, MReed, JC Naphthalene-based inhibitors of anti-apoptotic proteins US Patent US9115061 Publication Date 8/25/2015
More Info.:Get all data from this article,  Assay Method
 
Bcl-xL/BAK
Name:Bcl-xL/BAK
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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  Blast E-value cutoff:
BDBM174845
NameBDBM174845
Synonyms:US9115061, XII
TypeSmall organic molecule
Emp. Form.C40H34O8
Mol. Mass.642.6932
SMILESCc1ccc(CC(=O)c2c(O)c(O)cc3c(O)c(c(C)cc23)-c2c(C)cc3c(C(=O)Cc4ccc(C)cc4)c(O)c(O)cc3c2O)cc1 |(10.67,-13.86,;10.67,-12.32,;12,-11.55,;12,-10.01,;10.67,-9.24,;10.67,-7.7,;9.34,-6.93,;8,-7.7,;9.34,-5.39,;10.67,-4.62,;12,-5.39,;10.67,-3.08,;12,-2.31,;9.34,-2.31,;8,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,-3.08,;5.33,-4.62,;4,-5.39,;6.67,-5.39,;8,-4.62,;4,-2.31,;4,-.77,;5.33,,;2.67,,;1.33,-.77,;;,1.54,;1.33,2.31,;-1.33,2.31,;-1.33,3.85,;-2.67,4.62,;-2.67,6.16,;-1.33,6.93,;-1.33,8.47,;,6.16,;,4.62,;-1.33,-.77,;-2.67,,;-1.33,-2.31,;-2.67,-3.08,;,-3.08,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;9.34,-10.01,;9.34,-11.55,)|
Structure
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