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TargetBcl-2-like protein 1
LigandBDBM174843
Substrate/Competitorn/a
Meas. Tech.Isothermal Titration Calorimetry Assays
pH7.4±n/a
Kd 2750±n/a nM
Commentsextracted
Citation Pellecchia, MReed, JC Naphthalene-based inhibitors of anti-apoptotic proteins US Patent US9115061 Publication Date 8/25/2015
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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  Blast E-value cutoff:
BDBM174843
NameBDBM174843
Synonyms:US9115061, VIII
TypeSmall organic molecule
Emp. Form.C44H30O8
Mol. Mass.686.7042
SMILESCc1cc2c(C(=O)c3cccc4ccccc34)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)c3cccc4ccccc34)c(O)c(O)cc2c1O |(10.67,-4.62,;10.67,-3.08,;12,-2.31,;12,-.77,;13.34,,;14.67,-.77,;14.67,-2.31,;16,,;16,1.54,;17.34,2.31,;18.67,1.54,;18.67,,;20.01,-.77,;20.01,-2.31,;18.67,-3.08,;17.34,-2.31,;17.34,-.77,;13.34,1.54,;14.67,2.31,;12,2.31,;12,3.85,;10.67,1.54,;10.67,,;9.34,-.77,;8,,;9.34,-2.31,;8,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,-3.08,;5.33,-4.62,;4,-5.39,;2.67,-4.62,;1.33,-5.39,;2.67,-3.08,;4,-2.31,;4,-.77,;2.67,,;1.33,-.77,;;-1.33,-.77,;-1.33,-2.31,;,-3.08,;1.33,-2.31,;4,-6.93,;2.67,-7.7,;5.33,-7.7,;5.33,-9.24,;6.67,-6.93,;6.67,-5.39,;8,-4.62,;9.34,-5.39,)|
Structure
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