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Target
Protein Nef
Ligand
BDBM288164
Substrate
n/a
Meas. Tech.
Measurement of Antiviral (HIV-1) Activity
Temperature
298.15±n/a K
EC50
3.30±n/a nM
Comments
extracted
Citation
 Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent  US10087178 Publication Date 10/2/2018 
Target
Name:
Protein Nef
Synonyms:
3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef
Type:
C-terminal core protein
Mol. Mass.:
23340.47
Organism:
Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)
Description:
P03406
Residue:
206
Sequence:
MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
  
Inhibitor
Name:
BDBM288164
Synonyms:
(1S,2S)-N7'-(3-chloro-2- fluorobenzyl)-2'-cyclopropyl- 9'-hydroxy-N2,N2-dimethyl- 1',8'-dioxo-1',2',3',8'- tetrahydrospiro[cyclopropane- 1,4'-pyrido[1,2-a]pyrazine]- 2,7'-dicarboxamide | US10087178, Example T32
Type:
Small organic molecule
Emp. Form.:
C24H24ClFN4O5
Mol. Mass.:
502.923
SMILES:
CN(C)C(=O)[C@H]1C[C@@]11CN(C2CC2)C(=O)c2c(O)c(=O)c(cn12)C(=O)NCc1cccc(Cl)c1F |r|
Structure:
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