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Target
Aldehyde oxidase 1
Ligand
BDBM175348
Substrate
n/a
Meas. Tech.
AO Enzyme Assay
pH
7±n/a
Ki
1.60e+5± 1.98e+4 nM
IC50
1.15e+5±n/a nM
Comments
extracted
Citation
 Siah, M; Farzaei, MH; Ashrafi-Kooshk, MR; Adibi, H; Arab, SS; Rashidi, MR; Khodarahmi, R Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study. Bioorg Chem 64:74-84 (2016) [PubMed]  Article 
Target
Name:
Aldehyde oxidase 1
Synonyms:
AO | AOX1 | AOXA_CAVPO | Aldehyde oxidase (AO) | Aldehyde: O2 oxidoreductase
Type:
Protein
Mol. Mass.:
145280.02
Organism:
Cavia porcellus (Guinea pig)
Description:
H9TB17
Residue:
1332
Sequence:
MEPSTLYFYVNGRRVTEKNVDPETMLLPYLGRNLRLTGTKYGCGGGGCGACTVMVSRYDRGTGQIRHYPACACLTPLCSLHGAAVTTVEGVGSTRTRLHPVQERIAKSHGTQCGFCTPGMVMSLYALLRSHPQPSEEQLLEALAGNLCRCTGYRPILDAGKTFCKTSGCCQSKENGVCCLDQGVNGVQEAEGEQTSQELCSEEEFVPLDPTQELIFPPELMILAQKQPQKSRVFTGDRVTWISPVTLKDLLEAKAKNPRAPVVMGNTSVGPEMKFKGVFHPVIISPDGIEELSVIKQGNEGLTLGAGLSLAQVQDVLADVVQQLPEEKTQTLCALLKQLRTLAGSQIRNMASLGGHIMSRHLDSDLNPVLAAASCTLHVPSQEGDRQIPLDEHFLSRSPSADLRPQEVLLSVTIPYSRKWEFVSAFRQAQRKRSARAIVNVGMRVFFGAGDGVISELCILYGGVGPAIVCATDACRKLVGRHWTEEMLDEACRLVLGEVAIPGAAPGGRVEFRRTLLVSFLFRFYLQVSQSLSRMDPGRYPSLVGKYESALEDLCLGHHQRTFELQSADAKQLPQDPIGRPIMHLSGIKHTTGEAIYCDDMPLVDRELSLAFVTSSRAHAAILSMDLSEALSLPGVVDIVTAEHLGDANSFAKETLLATDKVLCVGHLVCAVIADSEVQAKRAAEKVKIVYQDLEPLILTIEEAIQHDSFFETERKLESGDVAEAFRTAEQVLEGSIHMGGQEHFYMETQSMLAVPKGEDQEIDLYVSTQFPTYIQEIVASTLKLPVNKVMCHVRRVGGAFGGKVGKTAILAAITAFAALKHCRAVRCILERGEDMLITGGRHPYLGKYKVGFRNNGQVVALDMEHYSNAGSTLDESLMVVEMGLLKMENAYKFPNLRCRGHACKTNLPSNTALRGFGFPQSGLITEACIVEVAARCGLSPEEVREVNMYRGTEQTHYGQEIHTQRLAQCWSECKAKATFSLRRAAVDRFNAGSPWKKRGLAMVPLKFPVGLGSVAMGQAAALVHVYLDGSVLLTHGGIEMGQGVHTKMIQVVSRELKMPMANVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKEWAQAAFDQSISLSAIGYFRGYDADMDWEKGKGHPFEYFVYGAACSEVEIDCLTGNHKNIRTDIVMDVGRSINPALDLGQVEGAFIQGMGLYTSEELKYGPQGALYTRGPDQYKIPAVCDVPAELHVFFLPPSKNSNTLYSSKGLGESGVFLGCSVLFAIWDAVSAARRERGLPGTLALSCPLTPEKIRMACEDRFTKMIPRDTPGSYVPWDVVV
  
Inhibitor
Name:
BDBM175348
Synonyms:
2',5'-di-Hydroxy Benzofuranone (2',5'-(OH)2) | 6-Hydroxy-2-(2',5'-dihydroxybenzylidene)benzofuran-3(2H) one
Type:
Small organic molecule
Emp. Form.:
C8H6O4
Mol. Mass.:
166.1308
SMILES:
OC1Oc2ccc(O)cc2C1=O
Structure:
Search PDB for entries with ligand similarity: